5-Amino-1MQ: Research Overview and Mechanism

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium compound, not a peptide. In research it is studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and sits within NAD+ and nicotinamide metabolism.

Because it is a small molecule rather than a lyophilized peptide, it is prepared per the research protocol rather than reconstituted like a peptide. The counterion matters: the iodide salt and the chloride salt differ in molecular weight, so the exact form should be confirmed against the supplier Certificate of Analysis.

Research using 5-Amino-1MQ examines NNMT enzyme inhibition and its downstream association with NAD+ and nicotinamide metabolism, primarily in cellular-metabolism and adipocyte-biology models. Mechanistically, NNMT transfers a methyl group from S-adenosylmethionine (SAM), the cell's principal methyl donor, onto nicotinamide, yielding 1-methylnicotinamide and S-adenosylhomocysteine. Because nicotinamide is also a precursor in the NAD+ salvage pathway, NNMT activity is studied as a node connecting cellular methylation capacity, NAD+ handling, and energy metabolism, which is why a small-molecule inhibitor is a useful tool for isolating that enzyme's contribution.

These are described as research applications reported in the literature, not human effects. The compound is used to probe NNMT-dependent pathways in preclinical settings.

The profile of 5-Amino-1MQ as an NNMT inhibitor was described by Neelakantan and colleagues in a 2018 report in Biochemical Pharmacology that examined small-molecule inhibition of nicotinamide N-methyltransferase in preclinical adipose-tissue and diet-induced-obesity models. This overview refers to that research record and does not describe a human effect.

Pinnacle 5-Amino-1MQ is a small molecule rather than a lyophilized peptide, supplied as the iodide salt (molecular formula C10H11IN2, near 286 g/mol, CAS 42464-96-0). Store the powder at -20°C protected from light and moisture, and dissolve it per the research protocol rather than reconstituting it with bacteriostatic water as a peptide would be. Because the counterion sets the molecular weight, the iodide and chloride forms differ, so confirm the exact salt against the lot-matched Certificate of Analysis, which also documents 99% or higher purity.