MOTS-C 10mg
Mitochondrial-Derived Peptide
Please allow an additional 3 to 5 business days of handling time for this compound.
A 16-residue mitochondrial-derived peptide studied within cellular-metabolism and AMPK-signaling research.
- COA included with every vial
- Free U.S. shipping over $200
- Secure encrypted checkout
- ≥99% doctoral chemist verified purity
RESEARCH APPLICATIONS
All products are intended strictly for in-vitro laboratory research and development use only. Not for human or veterinary use, not a drug, food, or cosmetic, and not intended to diagnose, treat, cure, or prevent any disease.
What is MOTS-C studied for in research?
MOTS-C is a 16-residue mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA rather than the nuclear genome. In research it is associated with AMPK-pathway signaling and with the folate and methionine cycles, and it is used as a tool compound in cellular-metabolism and mitochondrial-biology models. Most published work is preclinical; the peptide is not an approved drug and this material is supplied for research use only.
SEQUENCE
MRWQEMGYIFYPRKLR
Reconstitution & Handling
Reconstitute with bacteriostatic water. Do not shake vigorously.
Store at -20°C. Protect from light. Reconstitute and refrigerate.
Specifications
- Purity
- ≥99%
- Form
- Lyophilized powder
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2174.6 g/mol
- CAS Number
- 1627580-64-6
- Strength
- 10mg
Download the Certificate of Analysis
Doctoral chemist purity & identity report
Understand MOTS-C before you order
MOTS-C: Research Overview and Mechanism
MOTS-c is a 16-residue mitochondrial-derived peptide studied in laboratory and preclinical research for its association with AMPK signaling and metabolic homeostasis. Encoded within the mitochondrial 12S rRNA region, it is used as a tool compound in cellular-metabolism and mitochondrial-biology research. It is supplied as a lyophilized powder for research use only and is not approved for human use.
5-Amino-1MQ: Research Overview and Mechanism
5-Amino-1MQ is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), studied in laboratory and preclinical research for its association with NAD+ and nicotinamide metabolism. It is a non-peptide tool compound used in cellular-metabolism and adipocyte-biology research. It is supplied as a powder for research use only and is not approved for human use.
SS-31: Research Overview and Mechanism
SS-31 (elamipretide) is a mitochondria-targeted synthetic tetrapeptide studied in laboratory and preclinical research for its association with cardiolipin binding and mitochondrial bioenergetics. Under its development name elamipretide, the same molecule was evaluated in the Phase 3 MMPOWER-3 trial in primary mitochondrial myopathy and the TAZPOWER trial in Barth syndrome, and in September 2025 elamipretide HCl received FDA accelerated approval for Barth syndrome under the brand name FORZINITY, described as the first mitochondria-targeted therapeutic approved in the United States. That regulatory record is stated here as public fact; the material supplied is a lyophilized powder for research use only, not the approved drug product, and this overview describes what the molecule is studied for in research literature, not a therapeutic effect.
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MOTS-C Questions, Answered
What is MOTS-C studied for in research?
MOTS-C is studied as a mitochondrial-derived peptide within AMPK-pathway signaling, cellular metabolism, and mitochondrial-biology research models. Published work is largely preclinical, and this material is for research use only and not approved for human use.
What makes MOTS-C a 'mitochondrial-derived peptide'?
MOTS-C is encoded within the mitochondrial 12S rRNA region rather than the nuclear genome, one of a small set of peptides translated from mitochondrial DNA, which is why it is classified as a mitochondrial-derived peptide and studied in mitochondrial-signaling research.
How does MOTS-C differ from SS-31?
Both are short peptides studied in mitochondrial research, but MOTS-C is a genome-encoded signaling peptide linked to AMPK, whereas SS-31 is a synthetic tetrapeptide that concentrates at the inner membrane and binds cardiolipin. The full comparison is in the SS-31 vs MOTS-C guide at /learn/ss-31-vs-mots-c.
How should MOTS-C be handled?
MOTS-C is stored as a lyophilized powder at -20°C protected from light; after reconstitution with bacteriostatic water the solution is refrigerated, freeze-thaw cycles are minimized, and light exposure is limited, since the methionine residues in this peptide can be prone to oxidation.