Kisspeptin-10: Research Overview and Mechanism
Kisspeptin-10 is a C-terminally amidated decapeptide, the active KISS1R/GPR54 agonist fragment of the KISS1 gene product, studied in laboratory research within reproductive neuroendocrinology and the GnRH-axis signaling that sits at the apex of the hypothalamic-pituitary-gonadal axis. Kisspeptin-10 has also been investigated in published human clinical research on gonadotropin release within reproductive endocrinology. It is supplied as a lyophilized powder for research use only and is not approved for human use.
What Kisspeptin-10 is
Kisspeptin-10 is a C-terminally amidated decapeptide, with the sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 and a molecular weight near 1302.5 g/mol, corresponding to the shortest fully active fragment of the KISS1 gene product, kisspeptin. It is an agonist of the KISS1R receptor, also called GPR54.
Its C-terminal arginine-phenylalanine-amide (RFamide) motif is the part of the molecule essential for receptor binding, which is why the 10-residue fragment retains the activity of the longer parent peptide and serves as the standard tool compound for KISS1R signaling research.
Pathways it is studied within
In research, Kisspeptin-10 is studied as a KISS1R/GPR54 agonist on hypothalamic neurons, where receptor activation stimulates the release of gonadotropin-releasing hormone (GnRH). Because GnRH is the apex signal of the hypothalamic-pituitary-gonadal (HPG) axis, kisspeptin is used as an upstream tool for probing reproductive-neuroendocrine signaling in cellular and preclinical models.
Kisspeptin-10 has additionally been investigated in published human clinical research within reproductive endocrinology, where studies reported stimulation of luteinizing hormone (LH) release with a response that differed between men and women across the menstrual cycle. That describes the state of the literature in the third person; it is not a human-use claim for the material here, which is supplied for laboratory research only and is not approved for human use.
Handling and documentation
Pinnacle Kisspeptin-10 ships as a 5mg lyophilized powder, a smaller fill than the melanocortin peptides in this range. Its tryptophan residue is photosensitive and its C-terminal amide is essential to activity, so the sealed vial is stored at -20C shielded from light to protect both features before reconstitution.
Reconstitute with bacteriostatic water added gently against the inner wall, refrigerate the solution, and minimize freeze-thaw cycles, since the decapeptide degrades faster in solution than as a dry powder. Every batch is doctoral chemist tested by HPLC and mass spectrometry and ships with a lot-matched Certificate of Analysis.
All products are intended strictly for in-vitro laboratory research and development use only. Not for human or veterinary use, not a drug, food, or cosmetic, and not intended to diagnose, treat, cure, or prevent any disease.