KPV: Research Overview and Mechanism
KPV is the C-terminal tripeptide (lysine-proline-valine) of alpha-MSH, studied in laboratory and preclinical research within inflammation-pathway (NF-kB) and epithelial-barrier models. It is used as a compact peptide tool in melanocortin-related and inflammation research. It is supplied as a lyophilized powder for research use only and is not approved for human use.
What KPV is
KPV is a tripeptide composed of the amino acids lysine, proline, and valine, corresponding to residues 11 to 13 at the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). Its three-residue length is why it is described as a tripeptide, and its name is drawn from the single-letter codes of its amino acids.
Because it represents only the C-terminal fragment of alpha-MSH rather than the full sequence, it is used as a compact tool compound for studying that region in research models.
Pathways it is studied within
In research, KPV is studied within inflammation-signaling pathways and within epithelial-barrier research models. Mechanistic work in these models has associated it with downregulation of NF-kB pro-inflammatory signaling and, in intestinal-epithelial research, with uptake through the PepT1 peptide transporter. It is also referenced in melanocortin-related research owing to its origin in the C-terminal alpha-MSH sequence. These are research findings characterizing the tripeptide, not human outcomes.
Handling and documentation
Pinnacle KPV is supplied as a 10mg lyophilized powder (CAS 67727-97-3) with a lot-matched Certificate of Analysis. As a three-residue Lys-Pro-Val tripeptide it is a small molecule, roughly 342.4 g/mol against the C16H30N4O4 formula, which makes its mass-spectrometry identity check straightforward to read on the COA. Store the powder at -20C protected from light and reconstitute with bacteriostatic water.
All products are intended strictly for in-vitro laboratory research and development use only. Not for human or veterinary use, not a drug, food, or cosmetic, and not intended to diagnose, treat, cure, or prevent any disease.