What is Epithalon studied for in research?

In laboratory and preclinical research, Epithalon is studied within telomere biology (including telomerase and hTERT regulation), circadian and pineal regulation, and cellular-senescence models as a synthetic AEDG tetrapeptide. It is for research use only and is not approved for human use.

What is the Epithalon sequence?

Epithalon is the four-amino-acid peptide alanine-glutamate-aspartate-glycine (AEDG), molecular formula C14H22N4O9, a synthetic analog of the pineal peptide epithalamin studied as a tool compound in longevity research.

Is Epithalon doctoral chemist tested?

Yes. Each lot is analyzed by an independent laboratory using HPLC to measure purity and mass spectrometry to confirm identity, and the matching Certificate of Analysis reporting 99% or higher purity ships with the vial.

COMPOUND GUIDE 6 MIN READ

Epithalon: Research Overview and Mechanism

Epithalon (epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), studied in laboratory and preclinical research within telomere biology, circadian and pineal regulation, and cellular-senescence models. It is a compact analog of the pineal peptide epithalamin, supplied as a lyophilized powder for research use only and is not approved for human use. This overview reports how the tetrapeptide is characterized in the research record, not a therapeutic outcome for any individual.

What Epithalon is

Epithalon is a four-amino-acid peptide, alanine-glutamate-aspartate-glycine (AEDG, molecular formula C14H22N4O9, near 390.4 g/mol), developed as a synthetic analog of epithalamin, a peptide preparation associated with the pineal gland. Its short length makes it straightforward to synthesize precisely and to characterize analytically, which is part of why it is a frequently referenced tool compound in longevity-research literature.

Because it is a defined synthetic tetrapeptide, its identity is confirmed by mass spectrometry and its purity measured by HPLC, the same characterization applied to larger research peptides. It is also highly hydrophilic, so it dissolves in aqueous buffer without needing an organic co-solvent.

Pathways it is studied within

In research models, Epithalon is studied within telomere biology, where its investigated mechanism centers on the regulation of telomerase activity and the expression of the catalytic telomerase reverse transcriptase (hTERT) subunit in cultured cells. It is also examined within pineal and circadian regulation, reflecting its origin as an analog of the pineal preparation epithalamin, and within gene-expression and cellular-senescence endpoints.

Epithalon and the epithalamin preparation it models have additionally been the subject of human clinical-gerontology research reported in the Russian peptide-bioregulator literature. That body of work is described here in the third person as published research, not as evidence of an effect for any individual, and none of these pathways is a therapeutic claim.

Handling and documentation

Pinnacle Epithalon ships as a lyophilized powder with a lot-matched Certificate of Analysis reporting HPLC purity of 99% or higher and a mass-spectrometry identity check against the theoretical 390.4 g/mol mass of the C14H22N4O9 tetrapeptide. Store the sealed vial at -20C and keep it shielded from light.

Because AEDG is a short, highly hydrophilic four-residue sequence it dissolves readily in bacteriostatic water, but the reconstituted solution is still less stable than the dry powder: refrigerate it, aliquot to avoid repeated freeze-thaw cycles, and reconcile CAS 307297-39-8 against the COA before recording a molecular weight. See our reconstitution and storage guide for detail.

All products are intended strictly for in-vitro laboratory research and development use only. Not for human or veterinary use, not a drug, food, or cosmetic, and not intended to diagnose, treat, cure, or prevent any disease.