Hexarelin: Research Overview and Mechanism
Hexarelin (examorelin) is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor studied in laboratory and preclinical research for growth hormone-secretion signaling and for its noted interaction with the CD36 receptor. It is supplied as a lyophilized powder for research use only and is not approved for human use. Its dual engagement of GHS-R and the CD36 scavenger receptor is described here as reported laboratory pharmacology of the molecule, not a therapeutic effect.
What Hexarelin is
Hexarelin, also known as examorelin, is a synthetic six-residue peptide (His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2) that acts as an agonist of the growth hormone secretagogue receptor. Its molecular weight is near 887 g/mol.
It belongs to the growth hormone-releasing peptide family alongside GHRP-2 and GHRP-6, and it is distinguished in research literature by an additional noted interaction with the CD36 receptor, which makes it a point of comparison within secretagogue pharmacology.
Pathways it is studied within
In laboratory and preclinical research, Hexarelin is studied for GHS-R (ghrelin) receptor agonism, growth hormone-secretion signaling, CD36-receptor binding, and secretagogue pharmacology more broadly. Its distinguishing mechanistic feature is dual receptor engagement: alongside GHS-R1a it binds the scavenger receptor CD36, and preclinical cardiovascular research has examined this CD36 interaction independently of growth hormone release, which is why Hexarelin is used as a probe in comparative secretagogue and cardioprotection research models.
These pathways describe how the compound is studied in the literature, not human outcomes; Hexarelin has not received regulatory approval, and this product is supplied for research use only.
Handling and documentation
Pinnacle Hexarelin is a lyophilized hexapeptide (molecular weight near 887 g/mol) carrying the methylated tryptophan at position two that distinguishes it from GHRP-6; it is stored at -20C, protected from light, and reconstituted with bacteriostatic water for research use. Because comparative CD36 and secretagogue studies depend on an unambiguous molecule, each batch ships with a lot-matched Certificate of Analysis from HPLC and mass-spectrometry testing that confirms identity and purity.
All products are intended strictly for in-vitro laboratory research and development use only. Not for human or veterinary use, not a drug, food, or cosmetic, and not intended to diagnose, treat, cure, or prevent any disease.